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Cullen's sign is superficial edema and bruising in the subcutaneous fatty tissue around the umbilicus. It is named for Thomas Stephen Cullen (1869–1953), gynecologist who first described the sign in ruptured ectopic pregnancy in 1916.〔E. Cullen. Embryology, anatomy, and diseases of the umbilicus together with diseases of the urachus. Philadelphia, Saunders, and London, 1916.〕 This sign takes 24–48 hours to appear and can predict acute pancreatitis, with mortality rising from 8–10% to 40%. It may be accompanied by Grey Turner's sign (bruising of the flank), which may then be indicative of pancreatic necrosis with retroperitoneal or intraabdominal bleeding. ==Causes== Causes include: * acute pancreatitis, where methemalbumin formed from digested blood tracks around the abdomen from the inflamed pancreas * bleeding from blunt abdominal trauma * bleeding from aortic rupture * bleeding from ruptured ectopic pregnancy Importance of the sign is on a decline since better diagnostic modalities are now available. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cullen's sign」の詳細全文を読む スポンサード リンク
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